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• Sales Rank: #7684008 in Books
• Published on: 1600
• Binding: Mass Market Paperback

Most helpful customer reviews

1 of 1 people found the following review helpful.
But it is a very conversational and easy read. And if you're anything like me you'll ...
By Steve
An overall interesting read. Believer or not this one is worth a look if you have any interest in the subject whatsoever. Strieber makes some fantastically interesting points and hypothesis' on the visitor phenomena. And he himself, in this book, does not pin anything down to one thing. He approaches the subject with a completely open and thoughtful mind.
The only reason this book is not a five star book in my view is that at some points it does seem to drag on a bit.
But it is a very conversational and easy read. And if you're anything like me you'll tear through this book in under a week.
Recommended!

0 of 0 people found the following review helpful.
What if it really is a true story?
By Karen DeWitz
I read this book back in the 80s and bought this copy to return it to my collection. I have rarely read a book that led me so strongly to a feeling of "what if". The appendices (as well as the text) show that while it may or may not be a true story of ongoing alien encounters, the author believes it really happened. Intriguing and just a little bit edge-of-your-seat spooky.

0 of 0 people found the following review helpful.
An open-minded analysis of the phenomena that refuse to go away
By 3CatMama
The author looks deep and analyses his own and others' experience. His approach is thorough and as unbiased as any scientist can be. This approach is very satisfying intellectually and makes the writing dense. One must put this book down occasionally and think. Unfortunately the writing is not well-laid-out and hard to follow at times.

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[Y544.Ebook] Free PDF The Billion-Dollar Molecule: The Quest for the Perfect Drug, by Barry Werth

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Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing -- atom by atom -- both a new life-saving immunosuppressant drug, and a drug to combat the virus that causes AIDS.

You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating no-holds-barred account of the business of science, which includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.

• Sales Rank: #132962 in eBooks
• Published on: 2013-08-20
• Released on: 2013-08-20
• Format: Kindle eBook

Amazon.com Review
From test tubes to the Wall Street IPO and beyond, this is the riveting true story of a start-up pharmaceutical company working to create an anti-AIDS drug. Scientifically accurate, yet written with an attention to plot, timing, dialogue, and development of character more characteristic of the best thrillers.

From Publishers Weekly
A startup pharmaceutical company is the focus of this intriguing look at the nexus of biotechnology and high finance; features a new epilogue by the author.
Copyright 1995 Reed Business Information, Inc.

From Library Journal
Werth, a freelance writer on science and business issues, chronicles Joshua Boger's start-up of Vertex, a biotechnology company dedicated to the discovery of new drugs. Boger, a successful organic chemist with Merck, left his position as a senior director to establish Vertex. He recruited an exceptional group of researchers with the aim of integrating the most advanced disciplines in molecular biology to develop an immune-suppressing drug used in organ transplants and a potent HIV protease inhibitor to help thwart AIDS. Werth also discusses Vertex's financing and initial public stock offering. Recommended for science and business collections in public libraries and for special libraries in the pharmaceutical industry.
- Bruce Slutsky, New Jersey Inst. of Tech. Lib., Newark
Copyright 1994 Reed Business Information, Inc.

Most helpful customer reviews

35 of 37 people found the following review helpful.
difficult, fascinating, and compelling birth of a company
By Robert J. Crawford
This is the story of the first few years of Vertex, a bioventure that sought to create drugs that were constructed molecule by molecule - it is supposed to be "rational drug design". In exchange for allowing the company to check his work for accuracy and proprietary disclosures, Werth was admitted into the inner circle of the company, with both executives and scientists, for four years.

Werth offers masterful descriptions of both the science and the intricacies of the busisess deals. The work is similar to that of Tracy Kidder in "The Soul of a New Machine" and, in my opinion, of the same quality.

At the center of the story is Vertex's founding visionary, Joshua Boger, formerly a researcher at Merck. He reasoned that instead of screening soil samples and insect secretions in a hot or miss approach in thousands of petri dishes, he could design drugs atom by atom to bind to - and thus inactivate - molecules instrumental to the disease process. In theory, these drugs would be without side effects: because of the precision of the design, they would adhere to their target alone, allowing beneficial enzymes of other chem reactions to go on unimpeded.

Boger's first target molecule was FKBP, which he believed was a crucial agent of the immune system. By blocking it, he hoped to prevent the host's body from rejecting transplanted organs. While Boger was out raising money (eventually reaching $60 million), Vertex's researchers hunkered down to isolate and analyze FKBP, whose molecular mechanic remained poorly understood.

Unfortunately, what happened is a great example of the difficulties in marrying business to cutting-edge science: after over two years of pushing themselves to the brink of nervous collapse, Vertex scientists found difficulties with FKBP. Even worse, Boger's arch rival, a prof at Harvard, discovered why. The prof beat VErtex, Werth argues, because he remained outside the venture capital game and could thus concentrate totally on the science and could openly collaborate with them rather than hide proprietary results.

Nonetheless, driven and confident as ever, Boger turned his scientific team onto the new problem. Thru all of this, Boger comes off as a fascinating character: the son of a suicide, he is unshakably convinced that he can bend nature as well as the business world to his will. The reader sees what lies behind the herculean efforts of him and his team.

Warmly recommended as a rivetting tale of human endeavor that embraces the true complexity.

14 of 15 people found the following review helpful.
Fast-paced and Insightful
By EarlRandy
I first read this book nearly two years ago as research for a novel I was writing. Recently, I turned to it once more to pick up a few terms and found myself reading chapter after chapter!
This non-fiction tale has enough twists and turns and drama to match any thriller on the market. An informative and engaging tale of a pharmaceutical start-up and the people involved. Joshua is interesting enough that the book could have been solely about him, but he isn't the only one. All of the players in this ego-driven mega-drama are interesting on many levels.
Who would I reccomend this book to? Anyone who likes a well-told story. A background in medicine is not needed, and neither is a knowledge of business practices. All you need to enjoy this book is a brain . . . and a night light because you'll be reading this book deep into the night.

5 of 5 people found the following review helpful.
The Billion Dollar Molecule - One Company's Quest...
By thesheerans
A thouroughly enjoyable read, Werth sheds light on the personaliteis and complexities of an amazing and multifaceted business. Throughout, the author uncovers the unseen deal-making, hand-wringing, and fist clenching that dominate the start of Vertex, a strucure-based paharmaceutical firm.
I particularly enjoyed the background on the Boger-Schreiber collaboration and rivalry, and the ensuing rivalry in Vertex's own labs. Further, following the last few years of Vertex's ups and downs via the Internet has been thoroughly enjoyable.
Werth's style is easliy read, and his obvious unhindered access to Vertex and its people make the story enjoyable, suspenseful, and dramatic.

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[N402.Ebook] Get Free Ebook International Business Concepts, Environment, Structure & Strategy, by Sumati Varma

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• Published on: 2010-01-30
• Original language: English
• Dimensions: .0" h x .0" w x .0" l, 1.63 pounds
• Binding: Paperback
• 544 pages

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[Q976.Ebook] PDF Download Emotions: Freedom from Anger, Jealousy and Fear, by Osho

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This book is a simple guide to a better understanding of emotions. Anger, jealousy, and fear are the three big topics of this book, together with some simple meditations to deal with these emotions. The book consist of short quotes and text excerpts, giving the reader unusual and new insights into an understanding of emotions. Our feelings play a profound role in how we feel about ourselves, and they can even affect our physical health. Often we are trapped in the dilemma between "expression" and "repression." Although expressing our emotions can easily scare or hurt others, by repressing them we risk hurting ourselves. Osho offers a third alternative: to understand the roots of our emotions and develop the knack of watching them and learning from them as they arise, rather than being "taken over" by them. Eventually we find that even the most challenging and difficult situations no longer have the power to provoke us and cause us pain.

• Sales Rank: #39874 in Books
• Published on: 2013-10-15
• Original language: English
• Number of items: 1
• Dimensions: 6.00" h x 4.25" w x .50" l, .26 pounds
• Binding: Paperback
• 152 pages

About the Author
Osho is a contemporary mystic whose life and teachings have influenced millions of people of all ages, and from all walks of life. His often provocative and challenging teachings generate today more and more interest and his readership is dramatically expanding around the world in more than fifty languages. People can easily recognize the wisdom of his insights, and their relevance to our lives and to the issues we are facing today. The Sunday Times in London named Osho as one of the "1,000 Makers of the 20th Century". He is known around the world for his revolutionary contribution to meditation - the science of inner transformation - with the unique approach of his "OSHO Active Meditations" acknowledging the accelerated pace of contemporary life and bringing meditation into modern life.

Most helpful customer reviews

39 of 44 people found the following review helpful.
Not a Buddhist, but enjoyed it
By Amazon Customer
I'm not a Buddhist, but a Christian. I started reading, just to see what it was about and read the whole thing. The beginning is a very relaxing read and had some highlightable/clipable quotes. I do have different religious beliefs, this book offered some areas for further prayer and contemplation but I did not find these areas offensive so much as a beneficial exposure to a different perspective. Overall, I'm glad that I had a chance to read this book and learn a little about who OSHA is. Thanks to Amazon.com for having this book in Kindle format so I could start reading it in 60 seconds.

11 of 12 people found the following review helpful.
Great thoughts, weird at the end
By Jeremy Aldrich
This collection of Osho's wisdom, recorded from extemporaneous speeches rather than written all at once, offered many insights into the nature of negative and positive emotions. I definitely highlighted quite a few pearls like:
"Many people think that sentimentality is spirituality. But emotions are as mental as thoughts, and what you call your heart is as much in your head as your head. You can become emotional very easily. You can cry and weep with tears falling down, big pearl-like tears - but it is nothing spiritual."
"Sadness is passive anger and anger is active sadness."
"When you see anger in others, go and dig within yourself and you will find it there; when you see too much ego in others, just go inside and you will find ego sitting there. The inside functions like a projector; others become screens and you start seeing films on others which are really your own tapes."
"There is one and only one way to understand that to be angry is to be stupid: watch anger in all its phases, be alert to it so it does not catch you unawares; remain watchful, seeing every step of the anger. And you will be surprised: that as awareness about the ways of anger grows, the anger starts evaporating. And when the anger disappears, then there is a peace. Peace is not a positive achievement. When the hatred disappears, there is love. Love is not a positive achievement. When jealousy disappears, there is a deep friendliness towards all."

For me, the only thing that keeps this from being a five star book is the section at the end with "practical" suggestions on exercises for meditation, which are often pseudoscientific and almost all...well, weird.

The format wasn't perfect on the Kindle but the content was great.

17 of 20 people found the following review helpful.
Learn how to let go
By Upapalmtree
This book is excellent. You are not simply TOLD what to do about dealing with negative emotions, you are shown HOW and WHY! This is NOT just another self help book. This is a book I wish I had read ages ago. We are indeed all taught to suppress rather than channel our negative emotions. This book will show you how to get RID of them by acknowledging them and working through positive solutions.. rather than say grab a drug and addict yourself to trying to escape them (and you never will this way)..

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This text is intended for an advanced course in ground modification or engineering soil improvement at the senior or post-graduate level. It is designed to help engineers gain competence and creativity in devising alternative solutions to difficult foundation and earth construction problems and in evaluating the effectiveness of their solutions before, during and after construction. A range of ground modification techniques are presented, with a focus on how these techniques can help improve soil stability, reduce deformation, control seepage and increase erosion resistance.

• Sales Rank: #2359737 in Books
• Brand: Brand: Mcgraw-Hill College
• Published on: 1989-12
• Original language: English
• Number of items: 1
• Dimensions: 9.75" h x 7.00" w x 1.25" l,
• Binding: Hardcover
• 632 pages

Features

• Used Book in Good Condition

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• Sales Rank: #8598524 in Books
• Published on: 1984
• Binding: Hardcover

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• Sales Rank: #1722638 in Books
• Published on: 1991-06-01
• Original language: English
• Number of items: 1
• Dimensions: 9.00" h x 1.20" w x 6.00" l, .84 pounds
• Binding: Paperback
• 248 pages

About the Author
Robert B. Stepto is Professor of English, African American Studies, and American Studies at Yale University. He is the author of A Home Elsewhere: Reading African American Classics in the Age of Obama, Blue as the Lake: A Personal Geography, and From Behind the Veil: A Study of Afro-American Narrative. Among his edited volumes are Chant of Saints: A Gathering of Literature, Art, and Scholarship; Afro-American Literature: The Reconstruction of Instruction; and Harper American Literature.

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